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Erick Strauss

Stellenbosch University

65

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1732

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The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides

2021 Organic and Biomolecular Chemistry
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The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity.

2021 ACS Chemical Biology
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Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

2020 Science Advances
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Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents

2020 Frontiers in Cellular and Infection Microbiology
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Towards a stable and potent coenzyme A-targeting antiplasmodial agent: structure-activity relationship studies of N-phenethyl-α-methyl-pantothenamide

2020 ACS Infectious Diseases
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Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

2019 MedChemComm
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Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

2018
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Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

2018 Scientific Reports
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Probing the ligand preferences of the three types of bacterial pantothenate kinase

2018 Bioorganic & Medicinal Chemistry
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Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

2018 PLOS Pathogens
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