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Lei Guo

National Center for Toxicological Research
Food and Drug Administration

115

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7255

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Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance.

2021 Chemico-Biological Interactions
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The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells.

2021 Toxicology Letters
- Xilin Li
- Xiaobo He
- Si Chen
- Yuan Le
- Matthew Bryant
- Lei Guo
- Kristine L. Witt
- Nan Mei
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A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway

2021 Chemico-Biological Interactions
- Zhen Ren
- Si Chen
- Sery Pak
- Lei Guo
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Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity.

2021
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Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells.

2020 Archives of Toxicology
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Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing.

2020 Toxicological Sciences
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A comprehensive rat transcriptome built from large scale RNA-seq-based annotation

2020 Nucleic Acids Research
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Development and application of TK6-derived cells expressing human cytochrome P450s for genotoxicity testing.

2020 Toxicological Sciences
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Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene

2020 Methods of Molecular Biology
- Si Chen
- Dongying Li
- Zhen Ren
- Dianke Yu
- Baitang Ning
- Nan Mei
- Lei Guo
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Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline.

2020 Toxicology in Vitro
- Zhen Ren
- Si Chen
- Ji-Eun Seo
- Xiaoqing Guo
- Dongying Li
- Baitang Ning
- Lei Guo
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