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Yukako Asai

Nagoya University
Boston Children's Hospital

47

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Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

2019 Nature Medicine
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Allele-specific gene disruption through discrimination of a single base change by S. aureus Cas9-KKH prevents progressive hearing loss after AAV-mediated gene delivery

2019 Human Gene Therapy
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Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

2019 Human Gene Therapy
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Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

2019 Nature Communications
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Cysteine Substitution Reveals the Pore-Forming Region of TMC1 in Hair Cell Sensory Transduction Channels

2019 Biophysical Journal
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Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

2019 Nature Communications
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Regenerating hair cells in vestibular sensory epithelia from humans

2018 eLife
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Author response: Regenerating hair cells in vestibular sensory epithelia from humans

2018 eLife
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TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

2018 Neuron
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Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

2018 Scientific Reports
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