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Balkrishen Bhat

Isis Pharmaceuticals
Regulus Therapeutics

110

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mRNA therapeutics: beyond vaccine applications

2021 Trends in Molecular Medicine
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Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.

2021 Nucleic Acids Research
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Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles.

2021 Biomaterials
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Abstract 13074: Hypoxia-Driven Long Noncoding RNA KMT2E-AS1 Modulates Histone Methylation to Control Endothelial Metabolic Reprogramming and Pulmonary Hypertension

2019 Circulation
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A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions

2016 Scientific Reports
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P0907 : Pharmacokinetics, pharmacodynamics, and toxicity profile of RG-101, a novel GalNAc-conjugated hepatocyte-targetng inhibitor of microrna-122, in rodents and cynomolgus monkeys

2015 Journal of Hepatology
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suggesting active hypoxic pulmonary vasoconstriction in normoxia Inhaled nitric oxide alters the distribution of blood flow in the healthy human lung

2015
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The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension.

2015 Journal of Biological Chemistry
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Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

2015 Cell Reports
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P0904 : RG-101, A novel GalNAc-conjugated inhibitor of microrna-122, demonstrates significant viral load reduction and reduces liver steatosis in human hepatocyte chimeric mice infected with genotype 1A or hard-to-treat genotype 3A Hepatitis C Virus (HCV)

2015 Journal of Hepatology
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