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Carolyn Coles
Carolyn Coles
Chemistry
Acetylcholine receptor
Agonist
Biochemistry
Stereochemistry
4
Papers
23
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Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs
2019
ACS Medicinal Chemistry Letters
Andrew John Harvey
Thomas Avery
Laurent Schaeffer
Christophe Joseph
Belinda Huff
Rajinder Singh
Christophe Morice
Bruno Giethlen
Anton Grishin
Carolyn Coles
Peter Kolesik
S. Wagner
Emile Andriambeloson
B. Huyard
E. Poiraud
Dharam Paul
S. O Connor
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Citations (13)
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
2015
European Journal of Medicinal Chemistry
Corinne Beinat
Tristan A. Reekie
Samuel D. Banister
James O'Brien-Brown
Teresa Xie
Thao T. Olson
Yingxian Xiao
Andrew Harvey
Sue O'connor
Carolyn Coles
Anton Grishin
Peter Kolesik
John Tsanaktsidis
Michael Kassiou
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Citations (9)
Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333.
2014
European Journal of Medicinal Chemistry
Corinne Beinat
Tristan A. Reekie
David E. Hibbs
Teresa Xie
Thao T. Olson
Yingxian Xiao
Andrew Harvey
Sue O'connor
Carolyn Coles
John Tsanaktsidis
Michael Kassiou
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Citations (1)
Characterization of BNC375, a novel α7 nAChR positive allosteric modulator for the treatment of cognitive impairment in Alzheimer's disease
2013
Biochemical Pharmacology
Anton Grishin
B. Huyard
Carolyn Coles
Peter Kolesik
Y. Kolev
S. Wagner
E. Anddriambeloson
Andrew John Harvey
S. O Connor
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