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Michael R. Wood

Vanderbilt University
Vanderbilt University Medical Center

127

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VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate

2019 Bioorganic & Medicinal Chemistry Letters
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SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs

2019 Bioorganic & Medicinal Chemistry Letters
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Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

2019 Bioorganic & Medicinal Chemistry Letters
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Corrigendum to “Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides” [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]

2018 Bioorganic & Medicinal Chemistry Letters
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Optimization of M 4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

2017 Bioorganic & Medicinal Chemistry Letters
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Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

2017 Bioorganic & Medicinal Chemistry Letters
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Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

2017 Bioorganic & Medicinal Chemistry Letters
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Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

2017 ACS Medicinal Chemistry Letters
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Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

2017 Bioorganic & Medicinal Chemistry Letters
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Challenges in the development of an M PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides.

2017 Bioorganic & Medicinal Chemistry Letters
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