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Yang Xiang

The Microsoft Research - University of Trento Centre for Computational and Systems Biology

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A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment

2019 Internal and Emergency Medicine
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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment

2018 Food and Chemical Toxicology
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Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

2018 Toxicology Letters
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Generalized Simulated Annealing

2017
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The sbv IMPROVER Systems Toxicology computational challenge: Identification of human and species-independent blood response markers as predictors of smoking exposure and cessation status

2017 Computational Toxicology
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A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

2017 Toxicology in Vitro
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Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

2017 Food and Chemical Toxicology
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Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke

2016 Regulatory Toxicology and Pharmacology
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A framework for in vitro systems toxicology assessment of e-liquids

2016 Toxicology Mechanisms and Methods
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Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications:

2016 Gene regulation and systems biology
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