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Robert I. Horne
Robert I. Horne
University of Cambridge
Small molecule
Drug discovery
Synucleinopathies
Chemistry
flavone derivatives
3
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10
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0
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A Machine Learning Approach to Identify Specific Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation
2021
bioRxiv
Robert I. Horne
Andrea Possenti
Sean Chia
Faidon Brotzakis
Roxine Staats
Johnny Habchi
Michele Vendruscolo
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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers.
2021
Nature Communications
Francesco Simone Ruggeri
Johnny Habchi
Sean Chia
Robert I. Horne
Michele Vendruscolo
Tuomas P. J. Knowles
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Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
2020
Roxine Staats
Thomas C. T. Michaels
Patrick Flagmeier
Sean Chia
Robert I. Horne
Johnny Habchi
Sara Linse
Tuomas P. J. Knowles
Christopher M. Dobson
Michele Vendruscolo
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