ITPA

2CAR, 2I5D, 2J4E, 4F95370416434ENSG00000125877ENSMUSG00000074797Q9BY32Q9D892NM_001324238NM_001324240NM_001351739NM_025922NM_001362648NP_258412NP_852470NP_001338668NP_080198NP_001349577Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding.2car: CRYSTAL STRUCTURE OF HUMAN INOSINE TRIPHOSPHATASE2i5d: Crystal Structure of Human Inosine Triphosphate Pyrophosphatase2j4e: THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding. The protein encoded by this gene hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The enzyme possesses a multiple substrate-specificity and acts on other nucleotides including xanthosine triphosphate and deoxyxanthosine triphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency.