TRIB3

57761228775ENSG00000101255ENSMUSG00000032715Q96RU7Q8K4K2NM_001301201NM_144554NM_175093NP_066981NP_780302Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene. Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene. The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target TRIB3 has been shown to interact with: