Cubilin

3KQ4802965969ENSG00000107611ENSMUSG00000026726O60494Q9JLB4NM_001081NM_001081084NP_001072NP_001074553Cubilin is a protein that in humans is encoded by the CUBN gene. Cubilin is a protein that in humans is encoded by the CUBN gene. Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubilin shows a restricted mode of expression according to protein profiling and transcriptomics analyses, and is essentially only present in the kidneys and small intestine. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. A complex of amnionless and cubilin forms the cubam receptor. Cubilin is a potential diagnostic and prognostic cancer biomarker for kidney cancer. Based on patient survival data, high levels of cubilin in tumor cells is a favourable prognostic biomarker in renal cell carcinoma.