SPOP

2CR2, 3HQH, 3HQI, 3HQL, 3HQM, 3HTM, 3HU6, 3IVB, 3IVQ, 3IVV, 4EOZ, 4HS2, 4J8Z, 4O1V840520747ENSG00000121067ENSMUSG00000057522O43791Q6ZWS8NM_003563NM_025287NM_001359107NP_003554NP_079563NP_001346036Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.2cr2: Solution structure of N-terminal domain of speckle-type POZ protein Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers.