Aquaporin 3

36011828ENSG00000165272ENSMUSG00000028435Q92482Q8R2N1NM_004925NM_001318144NM_016689NP_001305073NP_004916NP_057898Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. In the kidney, AQP3 is regulated by vasopressin (ADH). This protein is also a determinant for the GIL blood group system. Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. In the kidney, AQP3 is regulated by vasopressin (ADH). This protein is also a determinant for the GIL blood group system. Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). AQP3 levels are often lower in psoriasis than in healthy skin. AQP3 is expressed more in atopic eczema.