PDE10A

2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8, 3WS9, 3WYK, 3WYL, 3WYM, 4AEL, 4AJD, 4AJF, 4AJG, 4AJM, 4BBX, 4DDL, 4DFF, 4FCB, 4FCD, 4HEU, 4HF4, 4LKQ, 4LLJ, 4LLK, 4LLP, 4LLX, 4LM0, 4LM1, 4LM2, 4LM3, 4LM4, 4MRW, 4MRZ, 4MS0, 4MSA, 4MSC, 4MSE, 4MSH, 4MSN, 4MUW, 4MVH, 4P0N, 4P1R, 4PHW, 4TPM, 4TPP, 4WN1, 4XY2, 4YQH, 4YS7, 4ZO5, 5C1W, 5C28, 5C29, 5C2A, 5C2H, 5DH5, 5AXQ, 5DH4, 5AXP, 5C2E, 5EDH, 5EDI, 5EDG, 5EDE, 5I2R, 5B4L, 5B4K1084623984ENSG00000112541ENSMUSG00000023868Q9Y233Q8CA95NM_001130690NM_006661NM_001290707NM_011866NM_001347321NP_001124162NP_006652NP_001277636NP_001334250NP_035996cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.2o8h: Crystal structure of the catalytic domain of rat phosphodiesterase 10A2oun: crystal structure of PDE10A2 in complex with AMP2oup: crystal structure of PDE10A2ouq: crystal structure of PDE10A2 in complex with GMP2our: crystal structure of PDE10A2 mutant D674A in complex with cAMP2ous: crystal structure of PDE10A2 mutant D674A2ouu: crystal structure of PDE10A2 mutant D674A in complex with cGMP2ouv: crystal structure of pde10a2 mutant of D564N2ouy: crystal structure of pde10a2 mutant D564A in complex with cAMP.2ovv: Crystal structure of the catalytic domain of rat phosphodiesterase 10A2ovy: Crystal structure of the catalytic domain of rat phosphodiesterase 10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene. Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate. Preliminary evidence indicates a possible link between PDE10A expression and obesity in mice and humans. This article incorporates text from the United States National Library of Medicine, which is in the public domain.