Tropomyosin receptor kinase C

1WWC, 3V5Q, 4YMJ491618213ENSG00000140538ENSMUSG00000059146Q16288Q6VNS1NM_001320135NM_008746NM_182809NP_002521NP_002521.2NP_032772NP_877961Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene.1wwc: NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival. The TrkC receptor is part of the large family of receptor tyrosine kinases. A 'tyrosine kinase' is an enzyme which is capable of adding a phosphate group to the certain tyrosines on target proteins, or 'substrates'. A receptor tyrosine kinase is a 'tyrosine kinase' which is located at the cellular membrane, and is activated by binding of a ligand via its extracellular domain. Other example of tyrosine kinase receptors include the insulin receptor, the IGF-1 receptor, the MuSK protein receptor, the Vascular Endothelial Growth Factor (or VEGF) receptor, etc. The 'substrate' proteins which are phosphorylated by TrkC include PI3 kinase. TrkC is part of a sub-family of protein kinases which includes TrkA and TrkB. Also, there are other neurotrophic factors structurally related to NT-3: NGF (for Nerve Growth Factor), BDNF (for Brain Derived Neurotrophic Factor) and NT-4 (for Neurotrophin-4). While TrkB mediates the effects of BDNF, NT-4 and NT-3, TrkA is bound and thereby activated only by NGF. Further, TrkC binds and is activated only by NT-3.