SOCS2

2C9W, 4JGH, 5BO48835216233ENSG00000120833ENSMUSG00000020027O14508O35717NM_003877NM_001168655NM_001168656NM_001168657NM_007706NP_003868NP_001162126NP_001162127NP_001162128NP_031732Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.2c9w: CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. SOCS2 has been shown to interact with insulin-like growth factor 1 receptor and erythropoietin receptor.