YWHAE

2BR9, 3UAL, 3UBW753122627ENSG00000274474ENSG00000108953ENSMUSG00000020849P62258P62259NM_006761NM_009536NP_006752NP_03356214-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.2br9: 14-3-3 PROTEIN EPSILON (HUMAN) COMPLEXED TO PEPTIDE 14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. YWHAE has been shown to interact with: