Sulforaphane promotes apoptosis, and inhibits proliferation and self-renewal of nasopharyngeal cancer cells by targeting STAT signal through miRNA-124-3p
2018
Abstract
Sulforaphane(SF) exhibits an anti-tumor effect in a variety of cancers, but little is known about its function in
nasopharyngeal carcinoma. SF could decrease the expression of
stem cell markers, β-catenin, Nanog, c-Myc, Oct3/4 and
Sox2in nasopharyngeal cancer cells (HONE1 and SUN1), and inhibit the formation of tumor spheres. Moreover, SF inhibits proliferation and induces apoptosis decreasing the stemness of nasopharyngeal cancer cells through a mechanism related to
STAT3signaling in vitro. We found that SF inhibits total
STAT3expression level and
STAT3phosphorylation (troy 704 and troy 705) by upregulation of miRNA-124-3p. Our results provide the evidence for discovering the novel drugs against
nasopharyngeal carcinoma, and potential drugs targeting
STAT3signaling pathway.
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