Detection of Post-Laser Vision Correction Ectasia with a new Combined Biomechanical Index.
2021
PURPOSE To validate and evaluate the use of a new biomechanical index known as the CBI-LVC (Corvis Biomechanical Index-Laser Vision Correction) as a method for separating stable post-LVC eyes from post-LVC eyes with ectasia. SETTING Patients were included from 10 clinics/9 countries. DESIGN Retrospective, multi-center, clinical study. METHODS The study was designed with two purposes: to develop the CBI-LVC, which combines dynamic corneal response parameters (DCR) provided by a high-speed Scheimpflug camera (Corvis ST, Oculus, Germany) and then to evaluate its ability to detect post-LVC ectasia. The CBI-LVC includes Integrated Inverse Radius, Applanation 1(A1) Velocity, A1-Deflection Amplitude, Highest Concavity-dArc Length, Deformation Amplitude ratio-2mm, and A1-ArcLength mm. Logistic regression with Wald forward stepwise approach was used to identify the optimal combination of DCRs to create the CBI-LVC, and then separate stable from LVC-induced ectasia. Eighty percent of the database was used for training the software and 20% for validation. RESULTS 736 eyes of 736 patients were included (685 stable LVC, and 51 post-LVC ectasia). The ROC curve analysis showed an AUC of 0.991 when applying CBI-LVC in the validation dataset and 0.998 in the training dataset. A cut-off of 0.2 was able to separate stable LVC from ectasia with a sensitivity of 93.3% and a specificity of 97.8%. CONCLUSIONS The CBI-LVC was highly sensitive and specific in distinguishing stable from ectatic post-LVC eyes. We suggest using CBI-LVC in routine practice, along with topography and tomography, to aid the early diagnosis of post-LVC ectasia and allow intervention prior to visually compromising progression.
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