Urokinase expression in course of benign and malignant mammary lesions: Comparison between nodular and healthy tissues
2010
Purpose Increased expression of
urokinase(uPA), a member of the
serine proteasefamily, is an effector of metastatic cascade and has been reported in various malignancies, including breast cancer. uPA overexpression in cancer tissues was correlated with a more aggressive phenotype and it is considered a strong and independent unfavorable prognostic factor in breast cancer.
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