Enantiomer-Selective High-Resolution Gas Chromatography (esHRGC)

Capillary gas chromatography (cG) has been an important separation technique for enantioselective chromatography from the early beginning of this research field in analytical chemistry. A number of early reports illustrate the importance of this separation technology for enantiomer separation. The relevance of enantioselective high resolution gas chromatography (HRGC) is summarised in several early monographs and review articles. A general survey is given in the earlier monographs by Konig (1987, 1992) and in recent review articles (Wong 2006; Xie and Yuan 2017; Gumustas et al. 2018), while the aspect “enantioselective gas chromatography of chiral environmental pollutants” was comprehensively introduced in earlier review articles (Huhnerfuss and Kallenborn 1992; Huhnerfuss 2000; Wong 2006). An extensive review of chiral stationary phases known until 1982 was first introduced by Liu and Ku (Liu and Ku 1983). Recent updates complement the comprehensive picture of all commercially available and tailor-made CSPs (Schurig 2001; Schurig 2010; Xiao et al. 2012; Peluso et al. 2014; Grajek et al. 2016). However, the recently reported updates are mainly reporting on modified CSPs originally reported already in the 1980s and 1990s. Only a few recent new developments are worth mentioning.