Factors Influencing Survival in Children with Atypical Teratoid/Rhabdoid Tumors (AT/RT): Single institute experience in developing country
2019
Abstract Aims and Objectives To evaluate the factors influencing overall survival (OS) and event-free survival (EFS) in children with ATRT. Materials and Methods This was a retrospective study with the inclusion criteria of children less than 16 years of age and tumor histology of ATRT. A univariate and multivariate analysis was done to determine the impact of individual and interdependency variables and the survival analysis. Results A total of 34 children were operated with a male to female ratio of 1.8:1. On univariate analysis, factors that had a statistically significant influence on OS and EFS were extent of resection (p=0.012; p=0.015), adjuvant therapy (p= Conclusion Achieving gross total resection should be the aim of surgery depending on location, and these children should be subjected to upfront adjuvant treatment.
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