Prevalence of serious post-training inhaler technique errors made by device-naïve patients using three different dry powder inhalers (DPIs)

Introduction: Many patients with asthma and COPD make serious inhalertechnique errors, which can impair dose delivery and have an adverse impact on clinical outcomes. Aim: To comparethe prevalence of serious inhalertechnique errors made by patients with asthma and/or COPD after training on DPIs in real life. Methods: Single visit, prospective, randomised, crossover study. Patients ≥18 years and naive to study devices were randomised to training on PulmoJet® and comparatorDPIs (Diskus® or Turbohaler®). Patients inhaledthrough empty devices after reading the patient information leaflet (PIL); if errors (those potentially affecting dose delivery) were observed they repeated the inhalationsafter video demonstration (PIL+video). Errors were recorded using nurse observed ( check list) and technological ( spirometry) methods. Conditional logistic regressionwas used to compareerrors for PulmoJet vs comparatorDPIs ( p Results: Of 431 patients, 421 eligible and 416 completed technological assessment. Patients were less likely to make errors using PulmoJet vs comparatordevices (table). Conclusion: Device-naive patients with asthma and/or COPD were significantly less likely to make serious inhalertechnique errors with PulmoJet comparedwith Diskus or Turbohaler after reading the patient information leaflet, both with and without additional video demonstration training.