Influenza antiviral resistance in the Asia-Pacific region during 2011
2013
Abstract Despite greater than 99% of influenza A viruses circulating in the Asia-Pacific region being resistant to the
adamantane
antiviral drugsin 2011, the large majority of influenza A (>97%) and B strains (∼99%) remained susceptible to the
neuraminidase inhibitors
oseltamivirand
zanamivir. However, compared to the first year of the 2009 pandemic, cases of
oseltamivir-resistant A(H1N1)pdm09 viruses with the H275Y
neuraminidasemutation increased in 2011, primarily due to an outbreak of
oseltamivir-resistant viruses that occurred in Newcastle, as reported in Hurt et al. (2011c, 2012a) , where the majority of the resistant viruses were from community patients not being treated with
oseltamivir. A small number of influenza B viruses with reduced
oseltamiviror
zanamivirsusceptibility were also detected. The increased detection of
neuraminidase inhibitorresistant strains circulating in the community and the detection of novel variants with reduced susceptibility are reminders that monitoring of influenza viruses is important to ensure that antiviral treatment guidelines remain appropriate.
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