Organoids to model liver disease

Summary The organoid model represents a major breakthrough in cell biology and has revolutionized biomedical research. Organoids are three-dimensional physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods. Liver organoids are of particular interest because of the pleiotropy of functions exerted by the human liver, their utility to model different liver diseases, and their potential application as cell-based therapies in regenerative medicine. Moreover, because they can be derived from patient tissues, organoid models offer new perspectives in personalized medicine and drug discovery. In this review, we discuss the current liver organoid models for the study of liver disease.