Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.

Laszlo Revesz,Birgit Bollbuck,Thomas Buhl,Joerg Eder,Ronald E. Esser,Roland Feifel,Richard Heng,Peter Hiestand,Bénédicte Jachez Demange,Pius Loetscher,Helmut Sparrer,Achim Schlapbach,Rudolf Waelchli

Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.

2005

Laszlo Revesz
Birgit Bollbuck
Thomas Buhl
Joerg Eder
Ronald E. Esser
Roland Feifel
Richard Heng
Peter Hiestand
Bénédicte Jachez Demange
Pius Loetscher
Helmut Sparrer
Achim Schlapbach
Rudolf Waelchli

Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.

Keywords:

Biochemistry
Arthritis
CCR1
Receptor
Chemistry
Collagen-induced arthritis
Ratón
Oral administration
Glycoprotein
Antagonist
Pharmacokinetics

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