POS0166 ASSOCIATION OF TRABECULAR BONE SCORE AND FAT DISTRIBUTION IN MOROCCAN RHEUMATOID ARTHRITIS PATIENTS

Background: The association between body composition and bone microarchitecture reflected by trabecular bone score (TBS) has been studied lately (1). In rheumatoid arthritis (RA), this association, especially with fat mass, needs further confirmation. Objectives: The purpose of the present work was to study the association of TBS with fat distribution in RA. Methods: We designed a cross-sectional study of patients with RA diagnosis according to ACR-EULAR 2010 classification recruited from first January 2021. Those with prior cancer, hyperparathyroidism, hyperthyroidism, diabetes, chronic kidney disease, cirrhosis, and a body mass index (BMI) of more than 36kg/m2 were excluded. TBS, total body fat mass (BFM), and its distribution (gynoid (GFM), android (AFM), visceral (VFM), limbs (LFM), trunk (TFM)) were measured with Dual-energy X-ray absorptiometry (Hologic). Clinical data and laboratory tests of the same day of the DXA scan were analyzed. The associations between TBS, BFM, and its distribution were studied by correlations and multiple linear regressions using SPSS 20. Results: Sixty-nine patients were included. Their mean age was 49.86 ± 14.33 years, mean DAS28CRP was 2.56 ± 1.27, and mean disease duration was 14.84 ± 10.99 years. Sixty-two (89.9%) were women, with 30 (48.4%) had menopause. The mean BMI was 26.46 ± 5.26 kg/m2, and 41 patients were obese (59.4%). In the Pearson correlation analysis, TBS was associated with BFM (p = 0.04), AFM (p = 0.001), TFM (p = 0.007), and VFM (p Conclusion: In RA patients, TBS was negatively associated with visceral and android fat mass. This result may explain the intriguing coexistence of high BMD and vertebral fractures in RA obese patients. References: [1]Lv S, Zhang A, Di W, et al. Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men. Sci Rep. 2016; 6:24935. Published 2016 Apr 26. doi: 10.1038/srep24935. Disclosure of Interests: None declared