Ancient animal genome architecture reflects cell type identities
2019
The level of conservation of ancient metazoan
gene order(
synteny) is remarkable. Despite this, the functionality of the vast majority of such regions in metazoan genomes remains elusive. Utilizing recently published single-cell expression data from several anciently diverging metazoan species, we reveal the level of correspondence between
cell typesand genomic
synteny, identifying genomic regions conferring ancient
cell typeidentity.
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