Acoustic Signature: a therapeutic ultrasound guidance technique with submillimeter accuracy

Accurate targeting is paramount for transcranial ultrasound procedures. Here we describe a new method for targeting transcranial ultrasound dubbed acoustic signature which uses acoustic feedback from a target's unique reflection patterns to guide the transducer to a previously defined orientation. We characterize the uniqueness and convergence of acoustic signatures on a macaque head phantom. We demonstrate submillimeter targeting accuracy using acoustic signature feedback with two transcranial ultrasound mechanical systems. This method provides an accurate and repeatable method for therapeutic transducer array placement.