Correlation between serum 25-hydroxyvitamin D3 and the severity of atopic dermatitis in children with allergic or nonallergenic sensitization

Purpose: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D3 levels and the severity of atopic dermatitis(AD), markers of atopy(total IgE, total eosinophil count, and eosinophil cationic protein) in AD children according to allergen sensitization. Methods: This cross-sectional study was carried out on 160 AD patients aged 1 to 18 years between March 2012 and August 2014. The AD patients (AD group) were subdivided into 2 categoriesaccording to the results of the allergic skin prick and Unicap tests: the allergic and nonallergic AD groups. We compared 25-hydroxyvitamin D3 levels between the AD and control groups. We also investigated relationships between serum 25-hydroxyvitamin D3 levels, the severity of AD, and markers of AD (total IgE, total eosinophil count, and eosinophil cationic protein) in the allergic and nonallergic AD groups. Results: The average 25-hydroxyvitamin D3 levels were 30.6± 11.7 and 23.7± 10.0 ng/mL, respectively, in the control and AD groups (P< 0.001). The average 25-hydroxyvitamin D3 levels were 19.7± 8.6 and 27.5± 9.8 ng/mL, respectively, in the allergic and nonallergic AD groups, with clinical implications (P< 0.001). The 25-hydroxyvitamin D3 levels were not significantly associated with SCORing Atopic Dermatitisindex in the allergic (P= 0.004, r= –0.092) or nonallergic (P= 0.610, r= –0.58) AD groups. The 25-hydroxyvitamin D3 levels were not significantly associated with the aforementioned markers of atopyin the AD group. Conclusion: These results suggest that 25-hydroxyvitamin D3 may play a role in the pathogenesis of AD. (Allergy Asthma Respir Dis 2015;3:213-218)