The relationship between HER2 expression and Lauren classification in Chinese gastric cancer patients.

4065 Background: Intestinal type of gastric cancer has a better prognosis than diffuse type and intestinal type tends to have a higher incidence rate of HER2 positive. However the prognosis value of HER2 is still controversial. There might be some factors affecting the HER2’s survival value. What is the relationship between HER2 expression and Lauren classification? We would also analyze the survival differences among the gastric cancer patients with different HER2 and Lauren classification status. Methods: All the patients received the detection of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry (IHC). HER2 amplification levels were detected when the result of IHC was 2+. Fluorescence in situ hybridization (FISH) analysis was carried out according to the manufacturer’s protocol using the PathVysion HER2 DNA Probe kit (LSI HER2/neu Spectrum OrangeTM/ chromosome 7 centromere probe (CEP) 17 Spectrum GreenTM). FISH positive was defined as HER2:CEP17 ratio ≥2. Any case with IHC 3+ or I...