Safety profile of 152 consecutive image-guided lung and liver tumor biopsies for molecular profiling (IMPACT-SG).

e22134 Background: Research biopsies play a critical role in facilitating biomarker driven clinical trials. The increasing requirement to perform comprehensive molecular analyses necessitates procurement of adequate amount of tissue. This study aims to examine the safety of multiple needle passes performed during research biopsies. Methods: We reviewed consecutive patients (pt) undergoing biopsies for molecular profiling or as part of a clinical trial (IMPACT-SG). Depending on location of pulmonary lesions, either a transbronchial (n = 29, 21G) or percutaneous (perc) biopsy (n = 86) using coaxial needle technique (17G outer; 18G cutting; 22G chiba) was performed. We collated variables such as lesion size, location, depth and number of needle passes, as well as procedure-related complications including pneumothorax and bleeding. Logistics regression analysis was employed to determine factors associated with complications. Results: Between Nov 11 and Nov 14, 152 pt underwent core and/or fine needle biopsy o...