Early CT signs in patients with acute middle cerebral artery occlusion: incidence of contrast staining and haemorrhagic transformations after intra-arterial reperfusion therapy

AIM To investigate how often early computed tomography (CT) signsare associated with blood–brain barrier (BBB) disruption and result in haemorrhagic transformations. MATERIALS AND METHODS Serial CT findings were prospectively evaluated in 61 patients with acute middle cerebral artery (MCA) occlusion who underwent initial CT examination within 3 h of stroke onset and who were treated with intra-arterial reperfusion therapywithin 6 h of stroke onset. Obscuration of the margin of the lentiform nucleusand loss of the insular ribbon were evaluated as early CT signsin the deep MCA territories. Cortical effacement was also evaluated. BBB disruption was defined as contrast medium staining in post-therapeutic CT just after reperfusion therapy. The relationship between pre-therapeutic early CT signsand post-therapeutic contrast staining or haemorrhagic transformations was investigated. RESULTS The frequency of early CT signsin the deep MCA territories was significantly higher than that of cortical effacement (68.9 versus 27.9%). There were significant correlations between pre-therapeutic early CT signsand post-therapeutic contrast staining in both the deep and superficial MCA territories. Compared with early CT signsin the deep MCA territories, cortical effacement had a significantly higher incidence of post-therapeutic contrast staining (54.8 versus 82.4%). Although not statistically significant, cortical effacement tended to develop into haemorrhagic transformations. There was no correlation between early CT signsin the deep MCA territories and haemorrhagic transformations. CONCLUSION Cortical effacement may be an advanced CT signwith BBB disruption and potential risk for haemorrhagic transformations. The presence of early CT signsin the deep MCA territories may not be a contraindication of reperfusion therapy.