Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3genes causing recurrent p.Lys36Met alterationsin headand neck squamous cell carcinomas. They show that tumors with these p.Lys36Met alterationscorrespond to a specific DNA methylation cluster along with tumors harboring previously described mutations in NSD1.