Ginseng (Panax ginseng Meyer) Oligopeptides Protect Against Binge Drinking-Induced Liver Damage through Inhibiting Oxidative Stress and Inflammation in Rats
2018
Panax
ginsengC.A. Meyer (
ginseng) is an edible and traditional medicinal herb, which is reported to have a wide range of biological activity and pharmaceutical properties. There were more studies on
ginsenosideand polysaccharides, but fewer on
ginseng
oligopeptides(GOPs), which are small molecule
oligopeptidesextracted from
ginseng. The present study was designed to investigate the effects and underlying mechanism of
ginseng
oligopeptide(GOPs) on
binge drinking-induced alcohol damage in rats. Sprague Dawley rats were randomly assigned to six groups (n = 10), rats in normal control group and alcohol model group was administered distilled water; rats in four GOPs intervention groups (at a dose of 0.0625, 0.125, 0.25, 0.5 g/kg of body weight, respectively) were administered GOPs once a day for 30 days. Experiment rats were intragastrically administered ethanol at a one-time dose of 7 g/kg of body weight after 30 days. The
liver injurywas measured through traditional liver enzymes, inflammatory cytokines, expression of oxidative stress markers, and histopathological examination. We found that the GOPs treatment could significantly improve serum alanine aminotransferase and aspartate aminotransferase, plasma lipopolysaccharide, and inflammatory cytokine levels, as well as the oxidative stress markers that were altered by alcohol. Moreover, GOPs treatment inhibited the protein expression of
toll-like receptor4, and repressed the inhibitor kappa Bα and nuclear factor-κB p65 in the liver. These findings suggested that GOPs have a significant protective effect on
binge drinking-induced
liver injury, and the mechanism possibly mediated by the partial inhibition of lipopolysaccharide—
toll-like receptor4-nuclear factor-κB p65 signaling in the liver.
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