Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

Aims/hypothesis The relationship between insulin secretion and the incidence of hypertension has not been well characterised. We hypothesised that both a parental history of diabetes and TCF7L2rs7903146 polymorphism, which increases susceptibility to diabetes because of impaired beta cellfunction, are associated with incident hypertension. In a separate cohort, we assessed whether low insulin secretion is related to incident hypertension.