Regio- and Diastereoselective Vinylogous Mannich Addition of 3-Alkenyl-2-oxindoles to α-Fluoroalkyl Aldimines

An efficient asymmetric vinylogousMannich (AVM) addition reactionof 3-alkenyl-2- oxindolesto α-fluoroalkyl aldimineshas been developed. This reaction provided various optical active α-alkylidene-δ-amino-δ-fluoroalkyl oxindolesin excellentyields, complete γ-site regioselectivity, and excellentdiastereoselectivities.