Impairment of neurocognitive functioning, motor performance and mood stability in hospitalized patients with euvolemic moderate and profound hyponatremia.

Abstract Background The impact of chronic moderate and profound hyponatremia on neurocognitive performance, motor skills and mood stability has not been investigated systematically so far while results regarding mild-to-moderate hyponatremia are inconsistent. Furthermore, it is not known whether treatment has an effect on outcome in these patients. Methods 130 hospitalized patients with confirmed euvolemic hyponatremia ([ Results The scores of all tested domains were significantly worse in the hyponatremia group (median [Na+] 122(119-126)mEq/L) as compared to the reference group (p Conclusion We demonstrate a clear association between lower levels of [Na+] beyond mild hyponatremia and impairment of neurocognitive and motor performance as well as mood disorders. Our analysis further suggests a causal role of hyponatremia in this context. However, there are apparent differences between the distinct tested domains warranting further investigations.