Esophageal Atresia in Twins Compared to Singletons: In Utero Manifestation and Characteristics

OBJECTIVE Esophageal atresia with/without tracheo-esophageal fistula (EA/TEF) is more common among twins. The detection of polyhydramnios might be altered in twins, leading to EA/TEF underdiagnosis, prenatally. The aim of the study was to compare the prenatal manifestation of EA/TEF between twins and singletons. METHODS A 12-year study of EA/TEF cases was performed at a tertiary center. Cases exhibiting 1) small/absent stomach or 2) polyhydramnios were considered "suspected"; cases with 3) esophageal pouch were considered "detected". We compared the rate and timing of appearance of these signs between the groups. RESULTS There were 76 cases of EA/TEF, of which 17 were a co-twin. All twin pairs were EA/TEF discordant. The prevalence of EA/TEF at our center was 1:750 for twins (1:319 monochorionic and 1:1133 dichorionic) and 1:2399 for singletons. The rate of small/absent stomach, polyhydramnios and pouch in twins vs singletons was 23.5%, 47.1%, 29.4% and 39.7%, 72.4%,34.5%, respectively (P = 0.2, P = 0.09 and P = 0.7). Esophageal pouch was detected earlier in twins (P = 0.03). Twins were scanned more frequently (X 1.8 times, P = 0.01). CONCLUSION EA/TEF is more prevalent in twins. Despite lower rate of polyhydramnios, twins were similarly detected prenatally as singletons, and this was accomplished earlier in pregnancy; perhaps reflecting more frequent scans. This article is protected by copyright. All rights reserved.