Pyrazolo [1,5-a] pyridines as inhibitors TRK

2012
A compound of formula (I): ** ** Formula where: A is X1 is CH or N; R1 is -C (O) NH2, -C (O) N (R7) 2, -C (O) N (R8) 2, -NR 7 C (O) R8, -NR7C (O) N (R7) 2, - NR 7 C (O) N (R8) 2, -NR 7 C (O) N (R9) 2; -C (O) OR7, -NR7C (O) OR7, -NR7C (O) OR8, -C (O) NR7R8, -C (O) NR 7 C (O) OR7, -C (O) NR 7 C (O) NH2, -C (O) NR 7 C (O) N (R7) 2 or H; each R2 is independently selected from H and alkyl of 1 to 6 carbon atoms; each R3 is independently selected from H, alkyl of 1 to 6 carbon atoms, -CN, -C (O) N (R7) 2, -OR7 and halogen, or both R 3 together with the carbon atom (C ) with which they are attached form a spiro cyclopropyl group bonded to the pyrrolidine; or R2 and R3 together with the carbon atom (C) with which they are attached form a cyclopropyl ring fused to the pyrrolidine; each R4 is independently selected from H, halogen, OR7, alkyl of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms substituted with 1 to 3 halogen, alkoxy of 1 to 6 carbon atoms substituted with 1 to 3 of halogen, -CN and -C (O) N (R7) 2; each R5 is independently selected from H and alkyl of 1 to 6 carbon atoms; each R6 is independently selected from H, alkyl of 1 to 6 carbon atoms, -CN, -OR7 and halogen; each R7 is independently selected from H, alkyl of 1 to 6 carbon atoms, or alkyl of 1 to 6 carbon atoms substituted with 1 to 3 -OH; each R8 is independently selected from H, alkyl of 1 to 6 carbon atoms, phenyl, benzyl, phenyl substituted with 1 to 3 groups independently selected from R6, benzyl substituted with 1 to 3 groups independently selected from R6 , a 5- to 6-membered unsubstituted alkyl having 1 to 2 heteroatoms independently selected from O and N, a 5- to 6-membered having from 1 to 2 heteroatoms independently selected from O and N is substituted with 1 to 3 groups independently selected from R6, a cycloalkyl of 3 to 6 carbon atoms unsubstituted cycloalkyl of 3 to 6 carbon atoms substituted with 1 to 3 groups independently selected from R6, heteroaryl 5 to 6 membered unsubstituted having from 1 to 2 heteroatoms independently selected from O and N, a 5- to 6-membered having from 1 to 2 hetero volumes independently selected from O and N which is substituted with 1 to 3 groups independently selected from R6; each R9 is alkyl of 1 to 6 carbon atoms and, together with the nitrogen atom (N) with which they are attached form a 5- to 6-membered unsubstituted or a 5- to 6-membered substituted with 1 to 3 groups independently selected from R6; m is 0, 1, 2, 3 or 4, n is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.
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