Factors influencing the age at onset in familial frontotemporal lobar dementia: Important weight of genetics

To quantify the effect of genetic factors and generations influencing the age at onset (AAO) in families with frontotemporal lobar dementia (FTD) due to C9ORF72GRN We studied 504 affected individuals from 133 families with C9ORF72GRN A generational effect influencing AAO was detected in both C9ORF72GRNC9ORF72ppGRNpC9ORF72GRN Our results provide original evidence that genetic modifiers strongly influence the AAO in C9ORF72GRN