Influence of renal function on vitamin K antagonist oral anticoagulation quality in non-valvular atrial fibrillation patients

Introduction Chronic kidney disease (CKD) has been related to poor quality of anticoagulation and an increased risk of bleeding. This study aims to evaluate the association between impaired renal function (eGFR Methods This is an ancillary analysis of the prospective NATURE AF registry (NAtionalTUnisianREgistry of Atrial Fibrillation). Between March and June 2017, we prospectively registered information of 912 patients with a recently diagnosed AF and they were followed for one year. Patients with CKD were in turn categorized according to their eGFR level (Stage 3A: 59–45 mL/min, Stage 3B: 44–30 mL/min, Stage 4:29-15 mL/min and Stage 5: Results A total of 103 patients (11.4%) had eGFR Table 1 ). Conclusions Early stages of CKD seem to be associated with poorer anticoagulation control in patients with non-valvular AF taking VKA but without statistically significant difference. Larger studies with longer follow-up are necessary.