023 Feasibility and Efficiency of Strategies For Updating Clinical Practice Guidelines

Background Exhaustive search strategies(ESS) for updating clinical practice guidelines (CPGs) recommendations are laborious and expensive. Highly sensitive and specific alternative search strategiesare necessary to improve the efficiency in recommendations updating. Objectives To compare alternative search strategiesagainst ESS Methods We ran three different search strategiesin a convenience sample of four CPGs from the CPGs National Programme in Spain: 1) Original ESS (gold standard); 2) Search strategyin the McMaster Premium LiteratUre Service (PLUS) database; and 3) Restrictive strategywith the least number of MeSH terms and text words from the original ESS. We retrieved the key references (which triggered an update) from the original ESS and evaluated their presence in the PLUS and restrictive strategiesresults. We calculated the sensitivity, specificity, precision, and accuracy for the PLUS and restrictive strategiescompared to the ESS. Results The overall number of references in the PLUS strategywas lower than in the ESS (39,133 versus 2,635). The PLUS strategyretrieved a range of 1.12% to 12.1% of the total number of references retrieved by the ESS per guideline. Discussion Our project assessed two novel restrictive search strategiesfor the updating of CPGs, which could reduce the workload while displaying similar results. Full final findings of this project will be presented at the GIN meeting. Implications for Guideline Developers/Users Our project has important implications for updating CPGs, informing on the feasibility and efficiency of two novel search strategies.