Recent advance in STAT3 signal pathway in glioblastomas

Glioblastomas remain the most clinically challenging primary brain tumors in adult, which has a dismal prognosis. Glioblastoma carries a dismal prognosis primarily due to its aggressive proliferation in the brain regulated by complex molecular mechanisms. This review will explore the relationship between glioblastoma and both signal transducer and activator of transcription 3 (STAT3) signal pathway, and introduce the inhibition of glioblastoma growth through effectively inhibiting STAT3 signal transduct pathway. Besides, we further discuss the signal pathway related to STAT3. Key words: Glioblastoma; Signal transducer and activator of transcription 3; Signaling pathway