ST2 is a biomarker of pediatric pulmonary arterial hypertension severity and clinical worsening.

Abstract Introduction Pediatric pulmonary hypertension (PH) is a severe disease defined by sustained elevation of pulmonary artery pressures, and pulmonary vascular resistance (PVR). Noninvasive diagnostic and prognostic markers that are more pulmonary vascular specific have been elusive because of disease heterogeneity and patient growth.introduction Research Question Is ST2 is associated with pulmonary hemodynamic and functional changes in pediatric pulmonary hypertension? Does ST2 improve mortality risk models in pediatric pulmonary hypertension? Study Design and Methods Two pediatric cohorts ( Results In adjusted (age, sex) analysis in the PAHB, ST2 was significantly associated with shorter six-minute walk distance (6MWD; p=0.03) and increased pulmonary vascular resistance index (PVRi; p=0.02). In adjusted longitudinal regression in the CHC cohort, ST2 was significantly associated with higher PVRi (p