Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH.
2015
Abstract The aim of our study was to investigate the inhibitory effects on
gastric acidsecretion of a single oral dose of a
proton pump inhibitor,
esomeprazole20 mg and omeprazole 20 mg. A total of 14
Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of
esomeprazole20 mg. Each administration was separated by a 7-day washout period. During the 6-hour study period, the average pH after administration of
esomeprazolewas higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of
esomeprazole20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively). In
Helicobacter pylori-negative healthy male subjects, single oral administration of
esomeprazole20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.
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