The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate
1985
The blood serum concentrations of
creatinineand the low molecular weight proteins
cystatin C, β2-microglobulin and
retinol-binding proteinwere measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenedi-aminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of
creatinine,
cystatin Cand β2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for
retinol-binding protein(r = 0.39). The calculated values of the glomerular elimination rate for
creatinineand
cystatin Cwere normally distributed in contrast to those for β2-microglobulin. The calculated glomerular elimination rate of
cystatin Cwas not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of
cystatin Cis a better measure of the glomerular filtration rate than the serum level of β2-microglobulin.
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