142: Predictors of Deep Vein Thrombosis in Patients Tested for Sars-CoV-2

INTRODUCTION: Since the detection of SARS-CoV-2, there have been descriptions of increased incidence of VTE in those with COVID-19 Despite the mounting evidence, little data exists on rates and predictors of VTE in SARS-CoV-2 positive individuals compared to negative patients with similar symptoms METHODS: Retrospective chart review of suspected SARS-CoV-2 infected individuals presenting to an Academic Medical Center in Baton Rouge, LA between 3/3/2020 and 5/13/2020 Patients were included if they were tested for SARS-CoV-2 and received a complex duplex ultrasound during the same admission Positive SARS-CoV-2 infection was confirmed via RT-PCR on nasopharyngeal swabs All patients received thromboprophylaxis per hospital guidelines We compared baseline demographics, laboratory data, outcomes, and mortality between SARS-CoV-2 positive and negative patients utilizing Mann-Whitney U and Chi-Square tests Logistic regression was used to identify predictive factors for DVT RESULTS: A total of 92 patients were included, of which 51 were positive for COVID (55%) 35 patients (38%) had an ultrasound confirmed DVT Patients in the SARS-CoV-2 negative group had more severe illness on presentation (evidenced by higher Charlson scores (p<0 005) and APACHE-II scores (p<0 001)) There were no significant differences in other typical VTE risk factors including age, BMI, smoking history, or diabetes Rates of DVT were significantly higher in SARS-CoV-2 positive patients (51%) compared to negative (22%, p<0 01) Logistic Regression showed that in addition to well known risk factors (mechanical ventilation, surgery during admission), a positive SARS-CoV-2 result placed hospitalized patients at elevated risk of developing DVT (X2 (1,4)=32 39, p<0 001) While not statistically significant in our population, there was a higher rate of mortality in SARS-CoV-2 positive patients with DVT (38 5%) compared to those without DVT (24%, p=0 368) CONCLUSIONS: Even with less severe illness on presentation, thromboprophylaxis, and no difference in typical risk factors, SARS-CoV-2 positive patients were more likely to develop DVT compared to negative patients with similar symptoms Further study is warranted to determine appropriate dosing strategies for VTE prophylaxis in COVID patients