Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort
2019
Abstract Background
Dupilumabis the first biologic available to treat
atopic dermatitis(AD). Its effectiveness and safety were demonstrated in clinical trials. Objective We sought to assess the effectiveness and safety of
dupilumabin adults with AD in a real-life French multicenter retrospective cohort. Methods Patients were included between March 2017 and April 2018. Efficacy outcomes were collected both at baseline and three months (M3), when available, including
SCORAD(Scoring
Atopic Dermatitis) and EASI (
Eczema Areaand
Severity Index) scores. Adverse events (AE) were recorded at the follow-up. Results We included 241 patients. The median follow-up time was 3.8±3.7 months. SCORAD75 and EASI75 were achieved in 27/163 (16.6%) and 40/82 (48.8%) patients, respectively. The median
SCORADand EASI at M3 were significantly lower compared with baseline (25±21 vs 56±27.4, p -9 and 4.1±6.8 vs 17.9±15.4, p -9 , respectively). Conjunctivitis was reported in 84/241 (38.2%) patients. The proportion of
eosinophilia(>500/mm 3 ) during follow-up (57%) was higher than at baseline (33.7%) (n=172, p -6 ).
Dupilumabwas stopped in 42 cases, 27 of which were due to an AE. Limitations No control group, missing data. Conclusion This real-life study demonstrated results similar to clinical trials, with regard to
dupilumabeffectiveness, but revealed a higher frequency of conjunctivitis and
eosinophilia.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
15
References
80
Citations
NaN
KQI