OPTICAL COHERENCE TOMOGRAPHY WITH ANGIOGRAPHY IN BEHÇET UVEITIS
2018
Purpose: Behcet
uveitisis a cause of
retinal vasculitis, with
fluorescein angiographybeing the gold-standard diagnostic exam. Optical coherence tomography with angiography (OCT-A) is a non-invasive exam that analyzes macular retinal circulation with high resolution, and therefore, could be a useful diagnostic exam in these patients. Material and methods: Analysis of 14 eyes of 8 patients with Behcet
uveitisfrom our institution that were examined by OCT A (AngioPlex®, Zeiss). Macular morphology, area,
perimeterand circularity of the
foveal avascular zone, as well as central internal and global macular vascular density were evaluated. We compared our results with healthy controls. Results: Mean visual acuity in the patient’s subgroup was 0,84±0,25 and 3 eyes had previous diagnosis of
retinal vasculitiswith
fluorescein angiography. Morphologically we found attenuation of the superficial and deep capillary plexus in 8 eyes, and in 1 of these eyes atrophy of the internal retinal layers was also found in a localized territory. In the
fovealavascular area, no statistically significant changes were observed in its area and
perimeter(p=0.804 and p=0.380 respectively), although we did find significant changes in its circularity (p=0.027). Vascular density was significantly altered in the internal (p=0.023) and global (p=0.028) macular parameters. Conclusion: We found changes in the macular microcirculation in patients with Behcet
uveitis, even in the absence of angiographic changes. Future studies with more patients are necessary to understand the clinical significance of these changes.
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